Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian migraine case-control cohort

Maher, B.H., Taylor, M., Stuart, S., Okolicsanyi, R. K., Roy, B., Sutherland, H. G., Haupt, Larisa M., & Griffiths, Lyn R. (2013) Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian migraine case-control cohort. Gene, 528(2), pp. 343-346.

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Abstract

Migraine is a common neurological disorder characterised by temporary disabling attacks of severe head pain and associated disturbances. There is significant evidence to suggest a genetic aetiology to the disease however few causal mutations have been conclusively linked to the migraine subtypes Migraine with (MA) or without Aura (MO). The Potassium Channel, Subfamily K, member 18 (KCNK18) gene, coding the potassium channel TRESK, is the first gene in which a rare mutation resulting in a non-functional truncated protein has been identified and causally linked to MA in a multigenerational family. In this study, three common polymorphisms in the KCNK18 gene were analysed for genetic variation in an Australian case-control migraine population consisting of 340 migraine cases and 345 controls. No association was observed for the polymorphisms examined with the migraine phenotype or with any haplotypes across the gene. Therefore even though the KCNK18 gene is the only gene to be causally linked to MA our studies indicate that common genetic variation in the gene is not a contributor to MA.

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ID Code: 62427
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.gene.2013.07.030
ISSN: 0378-1119
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Elsevier BV
Deposited On: 12 Sep 2013 01:43
Last Modified: 14 Apr 2014 22:17

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