Investigation of APOE isoforms and the association between APOE E3 and E4 with migraine in the Australian Caucasian population

Stuart, Shani, Donges, Bianca, Murrell, Melanie, Haupt, Larisa M., Lea, Rod A., & Griffiths, Lyn R. (2013) Investigation of APOE isoforms and the association between APOE E3 and E4 with migraine in the Australian Caucasian population. NeuroReport, 24(10), pp. 499-503.

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Abstract

Migraine is a debilitating neurovascular disease that is associated with pulsating head pain accompanied by nausea, vomiting, photophobia, phonophobia and sometimes visual sensory disturbances. Because of its role in nitric oxide regulation and interleukin release, apolipoprotein E (APOE) has been suggested to play a role in the migraine pathogenesis pathway. This study evaluated the potential role of three APOE variants in an Australian population and the role that they may play in susceptibility to migraine. The study found no significant association between the tested variants and migraine for any of the APOE variants investigated.

Impact and interest:

2 citations in Scopus
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ID Code: 62434
Item Type: Journal Article
Refereed: Yes
DOI: 10.1097/WNR.0b013e3283625f55
ISSN: 0959-4965
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Lippincott Williams & Wilkins
Deposited On: 12 Sep 2013 04:31
Last Modified: 04 Jul 2014 17:45

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