Molecular genetics of migraine

Stuart, Shani, Maher, Bridget H, Oikari, Lotta, & Griffiths, Lyn R. (2013) Molecular genetics of migraine. ELS.

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Migraine is a common neurological disorder with a significantly heritable component. It is a complex disease and despite numerous molecular genetic studies, the exact pathogenesis causing the neurological disturbance remains poorly understood. Although several known molecular mechanisms have been associated with an increased risk for developing migraine, there remains significant scope for future studies. The majority of studies have investigated the most plausible candidate genes involved in common migraine pathogenesis utilising criteria that takes into account a combination of physiological functionality in conjunction with regions of genomic association. Thus, far genes involved in neurological, vascular or hormonal pathways have been identified and investigated on this basis. Genome-wide association studies (GWAS) studies have helped to identify novel regions that may be associated with migraine and have aided in providing the basis for further molecular investigations. However, further studies utilising sequencing technologies are required to characterise the genetic basis for migraine.

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ID Code: 62460
Item Type: Journal Article
Refereed: No
DOI: 10.1002/9780470015902.a0022493
ISBN: 9780470015902
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 John Wiley & Sons
Deposited On: 12 Sep 2013 05:28
Last Modified: 17 Dec 2014 07:57

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