Cardiomyopathy classification : ongoing debate in the genomics era
McCartan, Charles, Mason, Robert, Jayasinghe, S. R., & Griffiths, Lyn R. (2012) Cardiomyopathy classification : ongoing debate in the genomics era. Biochemistry Research International, 2012, pp. 1-10.
Cardiomyopathies represent a group of diseases of the myocardium of the heart and include diseases both primarily of the cardiac muscle and systemic diseases leading to adverse effects on the heart muscle size, shape, and function. Traditionally cardiomyopathies were defined according to phenotypical appearance. Now, as our understanding of the pathophysiology of the different entities classified under each of the different phenotypes improves and our knowledge of the molecular and genetic basis for these entities progresses, the traditional classifications seem oversimplistic and do not reflect current understanding of this myriad of diseases and disease processes. Although our knowledge of the exact basis of many of the disease processes of cardiomyopathies is still in its infancy, it is important to have a classification system that has the ability to incorporate the coming tide of molecular and genetic information. This paper discusses how the traditional classification of cardiomyopathies based on morphology has evolved due to rapid advances in our understanding of the genetic and molecular basis for many of these clinical entities.
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|Item Type:||Journal Article|
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Copyright Owner:||Copyright 2012 Hindawi Publishing Corporation|
|Deposited On:||12 Sep 2013 23:38|
|Last Modified:||21 Oct 2013 05:05|
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