Investigation of homocysteine-pathway-related variants in essential hypertension

Fowdar, Javed Y., Lason, Marta V., Szvetko, Attila L., Lea, Rod A., & Griffiths, Lyn R. (2012) Investigation of homocysteine-pathway-related variants in essential hypertension. International Journal of Hypertension, 2012, pp. 1-9.

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Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke. Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders. To investigate the role of the homocysteine (Hcy) metabolism pathway in hypertension we conducted a case-control association study of Hcy pathway gene variants in a cohort of Caucasian hypertensives and age- and sex-matched normotensives. We genotyped two polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR C677T and MTHFR A1298C), one polymorphism in the methionine synthase reductase gene (MTRR A66G), and one polymorphism in the methylenetetrahydrofolate dehydrogenase 1 gene (MTHFD1 G1958A) and assessed their association with hypertension using chi-square analysis. We also performed a multifactor dimensionality reduction (MDR) analysis to investigate any potential epistatic interactions among the four polymorphisms and EH. None of the four polymorphisms was significantly associated with EH and although we found a moderate synergistic interaction between MTHFR A1298C and MTRR A66G, the association of the interaction model with EH was not statistically significant (

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ID Code: 62502
Item Type: Journal Article
Refereed: Yes
DOI: 10.1155/2012/190923
ISSN: 2090-0392
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Hindawi Publishing Corporation
Deposited On: 13 Sep 2013 02:27
Last Modified: 04 Jul 2014 03:50

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