Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits

Dongés, B., Haupt, Larisa M., Lea, Rod A., Chan, R.C.K., Shum, D.H.K., & Griffiths, Lyn R. (2012) Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits. Gene, 506(1), pp. 135-140.

View at publisher


Human memory is a complex neurocognitive process. By combining psychological and molecular genetics expertise, we examined the APOE ε4 allele, a known risk factor for Alzheimer's disease, and the COMT Val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults. To assess memory type we used a range of memory tests of both retrospective and prospective memory. Genotypes were determined using RFLP analysis and compared with mean memory scores using univariate ANOVAs. Despite a modest sample size (n=197), our study found a significant effect of the APOE ε4 polymorphism in prospective memory. Supporting our hypothesis, a significant difference was demonstrated between genotype groups for means of the Comprehensive Assessment of Prospective Memory total score (p=0.036; ε4 alleles=1.99; all other alleles=1.86). In addition, we demonstrate a significant interactive effect between the APOE ε4 and COMT polymorphisms in semantic memory. This is the first study to investigate both APOE and COMT genotypes in relation to memory in non-pathological adults and provides important information regarding the effect of genetic determinants on human memory.

Impact and interest:

5 citations in Scopus
Search Google Scholar™
6 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 62532
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.gene.2012.06.067
ISSN: 0378-1119
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Elsevier
Deposited On: 16 Sep 2013 00:53
Last Modified: 17 Sep 2014 04:43

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page