Association of a Notch 3 gene polymorphism with migraine susceptibility

Menon, S., Cox, H., Kuwahata, M., Quinlan, S., MacMillan, J., Haupt, L.M., Lea, R.A., & Griffiths, L.R. (2010) Association of a Notch 3 gene polymorphism with migraine susceptibility. Cephalalgia, 31(3), pp. 264-270.

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) shares common symptoms with migraine. Most CADASIL causative mutations occur in exons 3 and 4 of the Notch 3 gene. This study investigated the role of C381T (rs 3815188) and G684A (rs 1043994) single nucleotide polymorphisms (SNP) in exons 3 and 4, respectively, of the Notch 3 gene in migraine.


The first part of the study, in a population of 275 migraineurs and 275 control individuals, found a significant association between the C381T variant and migraine, specifically in migraine without aura (MO) sufferers. The G684A variant was also found to be significantly associated with migraine, specifically in migraine with aura (MA) sufferers. A follow-up study in 300 migraineurs and 300 control individuals did not show replicated association of the C381T variant with migraineurs. However, the G684A variant was again shown to be significantly associated with migraine, specifically with MA.


Further investigation of the G684A variant and the Notch 3 gene is warranted to understand their role in migraine.

Impact and interest:

13 citations in Scopus
10 citations in Web of Science®
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ID Code: 62538
Item Type: Journal Article
Refereed: Yes
DOI: 10.1177/0333102410381143
ISSN: 0333-1024
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Sage Publications Ltd.
Deposited On: 16 Sep 2013 01:28
Last Modified: 19 Jul 2017 07:01

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