Single nucleotide polymorphism in hsa-mir-196a-2 and breast cancer risk : a case control study

Jedlinski, Dominik J., Gabrovska, Plamena N., Weinstein, Stephen R., Smith, Robert A., & Griffiths, Lyn R. (2011) Single nucleotide polymorphism in hsa-mir-196a-2 and breast cancer risk : a case control study. Twin Research and Human Genetics, 14(05), pp. 417-421.

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Abstract

microRNAs are small, non-coding RNAs that influence gene expression on a post-transcriptional level. They participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. As they may have an effect on thousands of target mRNAs, single-nucleotide polymorphisms in microRNA genes might have major functional consequences, because the microRNA's properties and/or maturation may change. miR-196a has been reported to be aberrantly expressed in breast cancer tissue. Additionally, the SNP rs11614913 in hsa-mir-196a-2 has been found to be associated with breast cancer risk in some studies although not in others. This study evaluated the association between rs11614913 and breast cancer risk in a Caucasian case-control cohort in Queensland, Australia. Results do not support an association of the tested hsa-mir-196a-2 polymorphism with breast cancer susceptibility in this cohort. As there is a discrepancy between our results and previous findings, it is important to assess the role of rs11614913 in breast cancer by further larger studies investigating different ethnic groups.

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ID Code: 62582
Item Type: Journal Article
Refereed: Yes
DOI: 10.1375/twin.14.5.417
ISSN: 1839-2628
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 Cambridge University Press
Deposited On: 17 Sep 2013 02:32
Last Modified: 22 Jul 2014 23:11

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