Legacy of mutiny on the Bounty : founder effect and admixture on Norfolk Island

Macgregor, Stuart, Bellis, Claire, Lea, Rod A., Cox, Hannah, Dyer, Tom, Blangero, John, Visscher, Peter M, & Griffiths, Lyn R. (2009) Legacy of mutiny on the Bounty : founder effect and admixture on Norfolk Island. European Journal of Human Genetics, 18(1), pp. 67-72.

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The population of Norfolk Island, located off the eastern coast of Australia, possesses an unusual and fascinating history. Most present-day islanders are related to a small number of the 'Bounty' mutineer founders. These founders consisted of Caucasian males and Polynesian females and led to an admixed present-day population. By examining a single large pedigree of 5742 individuals, spanning >200 years, we analyzed the influence of admixture and founder effect on various cardiovascular disease (CVD)-related traits. On account of the relative isolation of the population, on average one-third of the genomes of present-day islanders (single large pedigree individuals) is derived from 17 initial founders. The proportion of Polynesian ancestry in the present-day individuals was found to significantly influence total triglycerides, body mass index, systolic blood pressure and diastolic blood pressure. For various cholesterol traits, the influence of ancestry was less marked but overall the direction of effect for all CVD-related traits was consistent with Polynesian ancestry conferring greater CVD risk. Marker-derived homozygosity was computed and agreed with measures of inbreeding derived from pedigree information. Founder effect (inbreeding and marker-derived homozygosity) significantly influenced height. In conclusion, both founder effect and extreme admixture have substantially influenced the genetic architecture of a variety of CVD-related traits in this population.

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ID Code: 62633
Item Type: Journal Article
Refereed: Yes
DOI: 10.1038/ejhg.2009.111
ISSN: 1476-5438
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 Nature Publishing Group
Deposited On: 18 Sep 2013 03:37
Last Modified: 02 Jul 2014 22:48

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