Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Bahlo, Melanie, Booth, David R., Broadley, Simon A., Brown, Matthew A., Foote, Simon J., Griffiths, Lyn R., Kilpatrick, Trevor J., Lechner-Scott, Jeanette, Moscato, Pablo, Perreau, Victoria M., Rubio, Justin P., Scott, Rodney J., Stankovich, Jim, Stewart, Graeme J., Taylor, Bruce V., Wiley, James, Clarke, Glynnis, Cox, Mathew B., Csurhes, Peter A., Danoy, Patrick, Drysdale, Karen, Field, Judith, Greer, Judith M., Guru, Preethi, Hadler, Johanna, McMorran, Brendan J., Jensen, Cathy J., Johnson, Laura J., McCallum, Ruth, Merriman, Marilyn, Merriman, Tony, Pryce, Karen, Tajouri, Lotfi, Wilkins, Ella J., Browning, Brian L., Browning, Sharon R., Perera, Devindri, Broadley, Simon, Butzkueven, Helmut, Carroll, William M., Chapman, Caron, Kermode, Allan G., Marriott, Mark, Mason, Deborah, Heard, Robert N., Pender, Michael P., Slee, Mark, Tubridy, Niall, & Willoughby, Ernest (2009) Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics, 41(7), pp. 824-828.
To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13-14 (rs703842, P = 5.4 x 10(-11); rs10876994, P = 2.7 x 10(-10); rs12368653, P = 1.0 x 10(-7)) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 x 10(-7); rs1569723, P = 2.9 x 10(-7)). Both loci are also associated with other autoimmune diseases. We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
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|Item Type:||Journal Article|
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Copyright Owner:||Copyright 2009 Nature Publishing Group|
|Deposited On:||18 Sep 2013 04:19|
|Last Modified:||18 Nov 2013 00:23|
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