Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

Mackenzie, Jason, Tajouri, Lotti, Szvetko, Attila, Weth, Verena, Moreau, Julie, Greer, Judith M., Csurhes, Peter A., Pender, Michael P., & Griffiths, Lyn R. (2009) Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population. Journal of the Neurological Sciences, 280(1-2), pp. 62-64.

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OBJECTIVE: To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population.

METHODS: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/-5 years) were included in the study. The LIF 3' UTR StuI polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence.

RESULTS: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3' UTR StuI polymorphism.

CONCLUSION: The results indicate that the LIF 3' UTR StuI polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility.

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ID Code: 62648
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.jns.2009.01.026
ISSN: 0022-510X
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 Elsevier
Deposited On: 18 Sep 2013 05:56
Last Modified: 01 Nov 2013 05:07

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