Cytogenetics of melanoma and nonmelanoma skin cancer

Carless, Melanie A. & Griffiths, Lyn R. (2008) Cytogenetics of melanoma and nonmelanoma skin cancer. In Reichrath , Jorg (Ed.) Sunlight, Vitamin D and Skin Cancer. Springer , New York, pp. 227-240.

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Cytogenetic analysis of melanoma and nonmelanoma skin cancers has revealed recurrent aberrations, the frequency of which is reflective of malignant potential. Highly aberrant karyotypes are seen in melanoma, squamous cell carcinoma, solar keratosis and Merkel cell carcinoma with more stable karyotypes seen in basal cell carcinoma, keratoacanthoma, Bowen’s disease, dermatofibrosarcomarotuberans and cutaneous lymphomas. Some aberrations were common amongst a number of skin cancer types including rearrangements and numerical abnormalities of chromosome 1, −3p, +3q, partial or entire trisomy 6, trisomy 7, +8q, −9p, +9q, partial or entire loss of chromosome 10, −17p, + 17q and partial or entire gain of chromosome 20. Combination of cytogenetic analysis with other molecular genetic techniques has enabled the identification of not only aberrant chromosomal regions, but also the genes that contribute to a malignant phenotype. This review provides a comprehensive summary of the pertinent cytogenetic aberrations associated with a variety of melanoma and nonmelanoma skin cancers.

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18 citations in Scopus
14 citations in Web of Science®
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ID Code: 62650
Item Type: Book Chapter
DOI: 10.1007/978-0-387-77574-6_18
ISBN: 9780387775746
ISSN: 0065-2598
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Springer New York LLC
Deposited On: 18 Sep 2013 06:13
Last Modified: 01 Nov 2013 05:30

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