Investigation between the S377G3 GATA-4 polymorphism and migraine

Sherin, Chikhani, Francesca, Fernandez, Karl, Poetter, Brendan, Toohey, Ron, Harvey, & Griffiths, Lyn R. (2008) Investigation between the S377G3 GATA-4 polymorphism and migraine. The Open Neurology Journal, 2(1), pp. 35-38.

View at publisher (open access)


Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (χ² = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.

Impact and interest:

Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

31 since deposited on 19 Sep 2013
3 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 62677
Item Type: Journal Article
Refereed: Yes
DOI: 10.2174/1874205X00802010035
ISSN: 1874-205X
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 the authors.
Deposited On: 19 Sep 2013 04:45
Last Modified: 06 Nov 2013 14:56

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page