Investigation between the S377G3 GATA-4 polymorphism and migraine

Sherin, Chikhani, Francesca, Fernandez, Karl, Poetter, Brendan, Toohey, Ron, Harvey, & Griffiths, Lyn R. (2008) Investigation between the S377G3 GATA-4 polymorphism and migraine. The Open Neurology Journal, 2(1), pp. 35-38.

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Abstract

Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (χ² = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.

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ID Code: 62677
Item Type: Journal Article
Refereed: Yes
DOI: 10.2174/1874205X00802010035
ISSN: 1874-205X
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 the authors.
Deposited On: 19 Sep 2013 04:45
Last Modified: 06 Nov 2013 14:56

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