Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility

Fernandez, Francesca, Esposito, Teresa, Lea, Rod A., Colson, Natalie J, Ciccodicola, Alfredo, Gianfrancesco, Fernando, & Griffiths, Lyn R. (2008) Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility. BMC Medical Genetics, 9(1), p. 109.

View at publisher (open access)

Abstract

Background Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.

Methods We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.

Results Our study did not show any association between the examined SNPs in our test population (P > 0.05).

Conclusion Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.

Impact and interest:

12 citations in Scopus
Search Google Scholar™
13 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 62678
Item Type: Journal Article
Refereed: Yes
DOI: 10.1186/1471-2350-9-109
ISSN: 1471-2350
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 BioMed Central Ltd.
Deposited On: 19 Sep 2013 05:01
Last Modified: 02 Jul 2014 22:51

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page