Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility

McCallum, L. K., Fernandez, F., Quinlan, S., Macartney, D. P., Lea, Rod A., & Griffiths, Lyn R. (2007) Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility. European Journal of Neurology, 14(6), pp. 706-707.

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Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable number tandem repeat (VNTR) in intron 8 of the dopamine transporter gene (DATInt8) in 550 migraine cases (401 with aura, 149 without aura) and 550 non-migraine controls. Chi-squared analysis of the DATInt8 revealed that the allele and genotype frequency distributions for migraine cases (including subtype analysis) and controls were not different (P > 0.1). These findings offer no evidence for an association of the DATInt8 with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk.

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ID Code: 62690
Item Type: Journal Article
Refereed: Yes
DOI: 10.1111/j.1468-1331.2007.01800.x
ISSN: 1468-1331
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Wiley-Blackwell Publishing Ltd.
Deposited On: 19 Sep 2013 06:23
Last Modified: 02 Jul 2014 22:54

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