Migraine genetics and prospects for pharmacotherapy

Colson, Natalie J., Fernandez, Francesca, & Griffiths, Lyn R. (2007) Migraine genetics and prospects for pharmacotherapy. Drug Development Research, 68(6), pp. 282-293.

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Migraine is a common complex neurological disorder with a well-known but poorly characterized genetic liability. The search for migraine susceptibility genes has been the focus of intense research. It is now believed that common migraine is not a single gene disorder, but attributable to several potentially interacting genetic variants. These variants may differ in each sufferer and interact with environmental factors to set the individual migraine threshold. This genetic liability may play an important role in the clinical heterogeneity seen in migraine and also in the variability of treatment response. This review will look at genetic loci implicated in migraine to date and consider their current or prospective role in migraine therapy. To elucidate the complex nature of migraine genetic liability, approaches that consider detailed endophenotypic profiles that encompass treatment response may provide much more relevant information than simple end diagnosis.

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ID Code: 62692
Item Type: Journal Article
Refereed: Yes
DOI: 10.1002/ddr.20192
ISSN: 1098-2299
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 John Wiley & Sons, Inc.
Deposited On: 19 Sep 2013 06:32
Last Modified: 06 Nov 2013 23:17

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