A pharmacogenomic evaluation of migraine therapy

Johnson, Matthew P., Fernandez, Francesca, Colson, Natalie J., & Griffiths, Lyn R. (2007) A pharmacogenomic evaluation of migraine therapy. Expert Opinion on Pharmacotherapy, 8(12), pp. 1821-1835.

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Migraine is a common idiopathic primary headache disorder with significant mental, physical and social health implications. Accompanying an intense unilateral pulsating head pain other characteristic migraine symptoms include nausea, emesis, phonophobia, photophobia and in approximately 20-30% of migraine cases, neurologic disturbances associated with the aura phase. Although selective serotonin (5-HT) receptor agonists (i.e., 5-HT(1B/1D)) are successful in alleviating migrainous symptoms in < or = 70% of known sufferers, for the remaining 30%, additional migraine abortive medications remain unsuccessful, not tested or yet to be identified. Genetic characterization of the migrainous disorder is making steady progress with an increasing number of genomic susceptibility loci now identified on chromosomes 1q, 4q, 5q, 6p, 11q, 14q, 15q, 17p, 18q, 19p and Xq. The 4q, 5q, 17p and 18q loci involve endophenotypic susceptibility regions for various migrainous symptoms. In an effort to develop individualized pharmacotherapeutics, the identification of these migraine endophenotypic loci may well be the catalyst needed to aid in this goal. In this review the authors discuss the present treatment of migraine, known genomic susceptibility regions and results from migraine (genetic) association studies. The authors also discuss pharmacogenomic considerations for more individualized migraine prophylactic treatments.

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ID Code: 62698
Item Type: Journal Article
Refereed: Yes
DOI: 10.1517/14656566.8.12.1821
ISSN: 1744-7666
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Informa Healthcare
Deposited On: 19 Sep 2013 06:18
Last Modified: 07 Nov 2013 01:08

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