Minor head trauma – induced sporadic hemiplegic migraine coma

Curtain, Robert P., Smith, Robert L., Ovcaric, Mick, & Griffiths, Lyn R. (2006) Minor head trauma – induced sporadic hemiplegic migraine coma. Pediatric Neurology, 34(4), pp. 329-332.

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Familial hemiplegic migraine is a severe, rare subtype of migraine. Gene mutations on chromosome 19 have been identified in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene (chromosome 19p13) for familial hemiplegic migraine. Recently a gene mutation (Serine-218-Leucine) for a dramatic syndrome associated with familial hemiplegic migraine, commonly named “migraine coma”, has implicated exon 5 of this gene. The occurrence of trivial head trauma, in such familial hemiplegic migraine patients, may also be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval. Sporadic hemiplegic migraine shares a similar spectrum of clinical presentation and genetic heterogeneity. The case report presented in this article implicates the involvement of the Serine-218-Leucine mutation in the extremely rare disorder of minor head trauma–induced migraine coma. We conclude that the Serine-218-Leucine mutation in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene is involved in sporadic hemiplegic migraine, delayed cerebral edema and coma after minor head trauma.

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ID Code: 62715
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.pediatrneurol.2005.08.033
ISSN: 0887-8994
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Elsevier Inc.
Deposited On: 20 Sep 2013 01:29
Last Modified: 07 Nov 2013 01:52

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