Focussing on genomic and phenomic correlations in respiration of non-melanotic skin cancers

Maguire, David J., Lintell, Nicholas A., McCabe, Michael, & Griffiths, Lyn R. (2005) Focussing on genomic and phenomic correlations in respiration of non-melanotic skin cancers. Advances in Experimental Medicine and Biology, 566, pp. 375-380.

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In recent years, with the development of techniques in modern molecular biology, it has become possible to study the genetic basis of carcinogenesis down to the level of DNA sequence. Major advances have been made in our understanding of the genes involved in cell cycle control and descriptions of mutations in those genes. These developments have led to the definition of the role of specific oncogenes and tumour suppressor genes in several cancers, including, for example, colon cancers and some forms of breast cancer. Work reported from our laboratory has led to the identification of a number of candidate genes involved in the development of non-melanotic skin cancers. In this chapter, we attempt to further explain the observed (phenomic) alterations in metabolic pathways associated with oxygen consumption with the changes at the genetic level.

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ID Code: 62736
Item Type: Journal Article
Refereed: Yes
Additional Information: Oxygen Transport to Tissue XXVI
DOI: 10.1007/0-387-26206-7_49
ISBN: 0-387-25062-X
ISSN: 0065-2598
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 Springer New York LLC
Deposited On: 20 Sep 2013 03:14
Last Modified: 08 Nov 2013 01:35

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