Reproducibility of gastric emptying in overweight and obese males

Horner, Katy M., Byrne, Nuala M., Cleghorn, Geoffrey J., & King, Neil A. (2014) Reproducibility of gastric emptying in overweight and obese males. Clinical Nutrition, 33(4), pp. 684-688.

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Abstract

Background & aim

To understand whether any change in gastric emptying (GE) is physiologically relevant, it is important to identify its variability. Information regarding the variability of GE in overweight and obese individuals is lacking. The aim of this study was to determine the reproducibility of GE in overweight and obese males.

Methods

Fifteen overweight and obese males [body mass index 30.3 (4.9) kg/m2] completed two identical GE tests 7 days apart. GE of a standard pancake breakfast was assessed by 13C-octanoic acid breath test. Data are presented as mean (±SD).

Results

There were no significant differences in GE between test days (half time (t1/2): 179 (15) and 176 (19 min), p = 0.56; lag time (tlag): 108 (14) and 104 (8) min, p = 0.26). Mean intra-individual coefficient of variation for t1/2 was 7.9% and tlag 7.5%. Based on these findings, to detect a treatment effect in a paired design with a power of 80% and α = 0.05, minimum mean effect sizes for t1/2 would need to be ≥14.4 min and tlag ≥ 8.1 min.

Conclusions

These data show that GE is reproducible in overweight and obese males and provide minimum mean effect sizes required to detect a hypothetical treatment effect in this population.

Impact and interest:

5 citations in Scopus
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2 citations in Web of Science®

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ID Code: 62746
Item Type: Journal Article
Refereed: Yes
Keywords: gastric emptying, reproducibility, obesity, breath test, study design
DOI: 10.1016/j.clnu.2013.09.002
ISSN: 0261-5614
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Copyright Owner: Copyright 2013 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Clinical Nutrition. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical Nutrition, [Vol 33, Issue 4, (2014)] DOI: 10.1016/j.clnu.2013.09.002
Deposited On: 22 Sep 2013 23:08
Last Modified: 08 Sep 2015 23:14

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