Feasibility of ranking articular cartilage conditions with non-destructive near-infrared spectroscopy with extension to the Mankin grading system

Moody, Hayley Ruscoe (2013) Feasibility of ranking articular cartilage conditions with non-destructive near-infrared spectroscopy with extension to the Mankin grading system. PhD thesis, Queensland University of Technology.

Abstract

Grading osteoarthritic tissue has, until now, been a laboratory process confined to research activities. This thesis establishes a scientific protocol that extends osteoarthritic tissue ranking to surgical practice. The innovative protocol, which now incorporates the structural degeneration of collagen, enhances the traditional Modified Mankin ranking system, enabling its application to real time decision during surgery. Because it is fast and without time consuming laboratory process, it would potentially enable the cataloguing of tissues in osteoarthritic joints in all compartments of diseased joints during surgery for epistemological study and insight into the manifestation of osteoarthritis across age, gender, occupation, physical activities and race.

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ID Code: 62760
Item Type: QUT Thesis (PhD)
Supervisor: Oloyede, Kunle & Crawford, Ross
Keywords: articular cartilage, histology, Mankin, near infrared spectroscopy, osteoarthritis, grading, second harmonic generation, pannus, collagen aggregation, degeneration
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 23 Sep 2013 03:34
Last Modified: 09 Sep 2015 21:50

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