Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine

Curtain, R., Lea, R.A., Quinlan, S., Bellis, C., Tajouri, L., Hughes, R., MacMillan, J., & Griffiths, L.R. (2004) Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine. Journal of the Neurological Sciences, 227(1), pp. 95-100.

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The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene on chromosome 19p13.2 performing an association analysis in 244 typical migraine-affected patients, 151 suffering from migraine with aura (MA), 96 with migraine without aura (MO) and 244 unaffected controls. The populations consisted of Caucasians only, and controls were age- and sex-matched. The results showed no significant difference between groups for allele frequency distributions of the (TA)n polymorphism even after separation of the migraine-affected individuals into subgroups of MA and MO affected patients. This is in contradiction to Mochi et al. who found a positive association of this variant with MO. Our study discusses possible differences between the two studies and extends this research by investigating circulating cholesterol levels in a migraine-affected population.

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ID Code: 62761
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.jns.2004.08.010
ISSN: 0022-510X
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Elsevier BV
Deposited On: 22 Sep 2013 23:34
Last Modified: 02 Jul 2014 23:02

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