The role of adenosine-related genes variants in susceptibility to essential hypertension

Wright, Kirsty, Tajouri, Lotti, Lea, Rod A., Ovcaric, Micky, Heux, Stephanie, Morin, Fabien, Bey, Wallid, Headrick, John P., & Griffiths, Lyn R. (2004) The role of adenosine-related genes variants in susceptibility to essential hypertension. Journal of Hypertension, 22(8), pp. 1519-1522.

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Abstract

OBJECTIVE:

To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH).

DESIGN:

Case-control association study investigating gene variants for the ADORA1, ADORA2a and ADA genes.

PARTICIPANTS:

The study used a cohort of 249 unrelated hypertensive individuals who were diagnosed with hypertension, and an age, sex and ethnically matched group of 249 normotensive controls.

RESULTS:

The association analysis indicated that both allele and genotype frequencies did not differ significantly between the case and control groups (P > 0.05) for any of the markers tested.

CONCLUSION:

The adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives. However, involvement of these genes and the adenosine system cannot be conclusively excluded from essential hypertension pathogenesis as other gene variants may still be involved.

Impact and interest:

8 citations in Scopus
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7 citations in Web of Science®

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ID Code: 62767
Item Type: Journal Article
Refereed: Yes
DOI: 10.1097/01.hjh.0000133723.16947.6d
ISSN: 0263-6352
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Lippincott Williams & Wilkins, Ltd.
Deposited On: 23 Sep 2013 00:17
Last Modified: 02 Jul 2014 22:57

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