An analysis of clinical characteristics in genetically linked migraine-affected pedigrees

Lea, R.A., Hilton, D.A., MacMillian, J.C., & Griffiths, L.R. (2003) An analysis of clinical characteristics in genetically linked migraine-affected pedigrees. Cephalalgia, 23(8), pp. 808-813.

View at publisher

Abstract

Migraine is a common complex disorder characterized by severe recurrent headache and usually accompanied by nausea and vomiting. Previous studies in our laboratory have utilized three large multigenerational Australian pedigrees affected with migraine to indicate that the disease is genetically heterogeneous, with linkage results implicating genomic susceptibility regions on both chromosomes 19p and Xq. The present study explores the possibility of a correlation between genetic and clinical heterogeneity in these affected pedigrees. Specifically, the clinical characteristics of migraine including subtype, age of onset, frequency, duration, and disease symptoms were compared between the migraine pedigrees, and gender differences were also assessed. Our exploratory analyses revealed no significant differences in any of the clinical characteristics tested between the chromosome 19-linked family and the two X-linked families. Also, we did not detect any differences in male vs. female clinical features for these pedigrees. In conclusion, migraine is considered to be a clinically and genetically heterogeneous disorder; however, our study provided no conclusive evidence that variation in genomic susceptibility region is related to heterogeneity at the clinical level in these migraine-affected pedigrees.

Impact and interest:

4 citations in Scopus
Search Google Scholar™
3 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 62769
Item Type: Journal Article
Refereed: Yes
DOI: 10.1046/j.1468-2982.2003.00578.x
ISSN: 1468-2982
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Sage Publications Ltd.
Deposited On: 23 Sep 2013 00:25
Last Modified: 02 Jul 2014 22:56

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page