Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer

Curran, Joanne E., Weinstein, Stephen R., & Griffiths, Lyn R. (2002) Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. Cancer Letters, 188(1-2), pp. 103-107.

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Abstract

Nuclear factor kappa-beta (NF-kappaB) is a transcription factor responsible for modulating the expression of many genes involved in cell proliferation, differentiation, apoptosis and metastasis. NF-kappaB interacts with IkappaB inhibitory proteins to regulate gene expression. This study investigated common variants within the genes coding for NF-kappaB and IkappaB, NFKB1 and NFKBIA, for involvement in sporadic breast cancer. Genotypes were determined in a population of breast cancer affected individuals and age-matched controls. Results do not support an involvement of the tested NFKB1 and NFKBIA polymorphisms in susceptibility to sporadic breast cancer, in the tested Caucasian population.

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48 citations in Scopus
47 citations in Web of Science®
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ID Code: 62816
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/S0304-3835(02)00460-3
ISSN: 0304-3835
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2002 Elsevier Ireland Ltd
Deposited On: 24 Sep 2013 01:16
Last Modified: 25 Oct 2013 00:49

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