Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer

Curran, Joanne E., Lea, Rod A., Rutherford, Sue, Weinstein, Stephen R., & Griffiths, Lyn R. (2001) Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer. International Journal of Cancer, 95(4), pp. 271-275.

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Abstract

We have utilized a cross-sectional association approach to investigate sporadic breast cancer. Polymorphisms in 2 candidate genes, ESRalpha and GRL, were examined in an unrelated breast cancer-affected and age-matched control population. Several polymorphic regions within the ESRalpha gene have been identified, and some alleles of these polymorphisms have been found to occur at increased levels in breast-cancer patients. Additionally, variations in GRL have the potential to disrupt cell transcription and may be associated with cancer formation. We analyzed 3 polymorphisms, from codons 10 (TCT to TCC), 325 (CCC to CCG) and 594 (ACA to ACG) of ESRalpha, and a highly polymorphic dinucleotide repeat, D5S207, located within 200 kb of the GRL. When allelic frequencies of the codon 594 (exon 8) ESR polymorphism were compared between affected and unaffected populations, a significant difference was observed (p = 0.005). Results from the D5S207 dinucleotide repeat located near GRL also indicated a significant difference between the tested case and control populations (p = 0.001). Allelic frequencies of the codon 10 and codon 325 ESR polymorphisms were not significantly different between populations (p = 0.152 and 0.181, respectively). Our results indicate that specific alleles of the ESR gene (alpha subtype) and a marker for the GRL gene locus are associated with sporadic breast-cancer development in the tested Caucasian population and justify further investigation of the role of these and other nuclear steroid receptors in the etiology of breast cancer.

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ID Code: 62820
Item Type: Journal Article
Refereed: Yes
ISSN: 1097-0215
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2001 John Wiley & Sons, Inc.
Copyright Statement: The definitive version is available at www3.interscience.wiley.com
Deposited On: 24 Sep 2013 01:59
Last Modified: 11 Oct 2013 04:45

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