Composites for delivery of therapeutics : combining melt electrospun scaffolds with loaded electrosprayed microparticles

Bock, Nathalie, Woodruff, Maria A., Steck, Roland, Hutmacher, Dietmar, Farrugia, Brooke L., & Dargaville, Tim R. (2014) Composites for delivery of therapeutics : combining melt electrospun scaffolds with loaded electrosprayed microparticles. Macromolecular Bioscience, 14(2), pp. 202-214.

[img] Published Version (PDF 1MB)
Administrators only | Request a copy from author

View at publisher

Abstract

A novel strategy is reported to produce biodegradable microfiber-scaffolds layered with high densities of microparticles encapsulating a model protein. Direct electrospraying on highly porous melt electrospun scaffolds provides a reproducible scaffold coating throughout the entire architecture. The burst release of protein is significantly reduced due to the immobilization of microparticles on the surface of the scaffold and release mechanisms are dependent on protein-polymer interactions. The composite scaffolds have a positive biological effect in contact with precursor osteoblast cells up to 18 days in culture. The scaffold design achieved with the techniques presented here endorses these new composite scaffolds as promising templates for growth factor delivery.

Impact and interest:

7 citations in Scopus
Search Google Scholar™
5 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 62833
Item Type: Journal Article
Refereed: Yes
Keywords: Drug Delivery, Electrospraying, Microstuructures, Polymer-Drug Interactions, Tissue Engineering
DOI: 10.1002/mabi.201300276
ISSN: 1616-5187
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Medical Devices (090304)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200) > Composite and Hybrid Materials (091202)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Pharmaceutical Sciences (111504)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Copyright Statement: The definitive version is available at www3.interscience.wiley.com
Deposited On: 24 Sep 2013 22:20
Last Modified: 24 Aug 2016 01:25

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page