Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer
Smith, Robert A., Curran, Joanne E., Weinstein, Stephen R., & Griffiths, Lyn R. (2001) Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer. Breast Cancer Research, 3(6), pp. 409-411.
Background Certain genes from the glutathione S-transferase superfamily have been associated with several cancer types. It was the objective of this study to determine whether alleles of the glutathione S-transferase zeta 1 (GSTZ1) gene are associated with the development of sporadic breast cancer.
Methods DNA samples obtained from a Caucasian population affected by breast cancer and a control population, matched for age and ethnicity, were genotyped for a polymorphism of the GSTZ1 gene. After PCR, alleles were identified by restriction enzyme digestion and results analysed by chi-square and CLUMP analysis.
Results Chi-squared analysis gave a χ2 value of 4.77 (three degrees of freedom) with P = 0.19, and CLUMP analysis gave a T1 value of 9.02 with P = 0.45 for genotype frequencies and a T1 value of 4.77 with P = 0.19 for allele frequencies.
Conclusion Statistical analysis indicates that there is no association of the GSTZ1 variant and hence the gene does not appear to play a significant role in the development of sporadic breast cancer.
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|Item Type:||Journal Article|
|Keywords:||glutathione S-transferase zeta, GSTZ1, sporadic breast cancer|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)|
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Copyright Owner:||Copyright 2001 Smith et al., licensee BioMed Central Ltd|
|Deposited On:||24 Sep 2013 03:21|
|Last Modified:||08 Aug 2014 08:12|
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