Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer

Smith, Robert A., Curran, Joanne E., Weinstein, Stephen R., & Griffiths, Lyn R. (2001) Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer. Breast Cancer Research, 3(6), pp. 409-411.

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Background Certain genes from the glutathione S-transferase superfamily have been associated with several cancer types. It was the objective of this study to determine whether alleles of the glutathione S-transferase zeta 1 (GSTZ1) gene are associated with the development of sporadic breast cancer.

Methods DNA samples obtained from a Caucasian population affected by breast cancer and a control population, matched for age and ethnicity, were genotyped for a polymorphism of the GSTZ1 gene. After PCR, alleles were identified by restriction enzyme digestion and results analysed by chi-square and CLUMP analysis.

Results Chi-squared analysis gave a χ2 value of 4.77 (three degrees of freedom) with P = 0.19, and CLUMP analysis gave a T1 value of 9.02 with P = 0.45 for genotype frequencies and a T1 value of 4.77 with P = 0.19 for allele frequencies.

Conclusion Statistical analysis indicates that there is no association of the GSTZ1 variant and hence the gene does not appear to play a significant role in the development of sporadic breast cancer.

Impact and interest:

8 citations in Scopus
9 citations in Web of Science®
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ID Code: 62848
Item Type: Journal Article
Refereed: Yes
Keywords: glutathione S-transferase zeta, GSTZ1, sporadic breast cancer
DOI: 10.1186/bcr332
ISSN: 1465-5411
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2001 Smith et al., licensee BioMed Central Ltd
Deposited On: 24 Sep 2013 03:21
Last Modified: 08 Aug 2014 08:12

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