Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments

Rogers, Kelly L., Grice, I. Darren, & Griffiths, Lyn R. (2000) Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments. European Journal of Pharmaceutical Sciences, 9(4), pp. 355-363.

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To identify potential migraine therapeutics, extracts of eighteen plants were screened to detect plant constituents affecting ADP induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT) release. Extracts of the seven plants exhibiting significant inhibition of platelet function were reanalysed in the presence of polyvinyl pyrrolidone (PVP) to remove polyphenolic tannins that precipitate proteins. Two of these extracts no longer exhibited inhibition of platelet activity after removal of tannins. However, extracts of Crataegus monogyna, Ipomoea pes-caprae, Eremophila freelingii, Eremophila longifolia, and Asteromyrtus symphyocarpa still potently inhibited ADP induced human platelet [14C]5-HT release in vitro, with levels ranging from 62 to 95% inhibition. I. pes-caprae, and C. monogyna also caused significant inhibition of ADP induced platelet aggregation. All of these plants have been previously used as traditional headache treatments, except for C. monogyna which is used primarily for protective effects on the cardiovascular system. Further studies elucidating the compounds that are responsible for these anti-platelet effects are needed to determine their exact mechanism of action.

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ID Code: 62862
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/S0928-0987(99)00074-3
ISSN: 0928-0987
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2000 Elsevier BV
Deposited On: 24 Sep 2013 05:19
Last Modified: 23 Oct 2013 05:14

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