Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer susceptibility

Curran, Joanne E., Weinstein, Stephen R., & Griffiths, Lyn R. (2000) Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer susceptibility. Cancer Letters, 153(1-2), pp. 113-120.

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Abstract

The glutathione S-transferase (GST) family of enzymes function in the body to detoxify carcinogenic compounds. Several genes that code for these enzymes are polymorphic, with particular genotypes previously shown to confer an increased cancer risk. In this study, we investigated the role of three GST genes (GSTM1, GSTP1 and GSTT1) in the development of sporadic breast cancer. Genotypes were determined in 129 breast cancer affected and 129 age and sex matched control individuals. Results did not support an involvement of these specific GST gene polymorphisms, either independently or in combination, in susceptibility to sporadic breast cancer in the tested Australian Caucasian population.

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ID Code: 62863
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/S0304-3835(00)00361-X
ISSN: 0304-3835
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2000 Elsevier Ireland Ltd
Deposited On: 24 Sep 2013 05:23
Last Modified: 24 Sep 2013 05:23

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