Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension

Zee, Robert Y., Lou, Yi-kun, Griffiths, Lyn R., & Morris, Brian J. (1992) Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochemical and Biophysical Research Communications, 184(1), pp. 9-15.

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A polymorphism of the angiotensin I converting enzyme (ACE) gene has recently been reported and analysis of this polymorphism has indicated that it is associated with several cardiovascular diseases. However, the results are still controversial and such association has not yet been established conclusively. To determine whether the ACE gene may be responsible for essential hypertension in a Japanese population, we also compared the distribution of genotypes and the allele frequency of this polymorphism in our findings of a Japanese population with these features in other countries. Eighty-seven hypertensive patients with a family history of essential hypertension and 95 normotensive patients whose parents had no such history were enrolled in the study. Polymorphism of the ACE gene was determined by using the polymerase chain reaction. Homozygotes for this polymorphism had either a 490-bp band (II) or a 190-bp band (DD) and heterozygotes had both bands (ID). In hypertensive subjects, the numbers and frequency of the ACE genotypes were: II, 44 (0.51); ID, 26 (0.30); DD, 17 (0.19). In normotensive subjects these were: II, 35 (0.37); ID, 43 (0.45); DD, 17 (0.18). There were no significant differences between the two groups in derived allele frequencies (chi 2 = 1.41). The difference between the overall allelic frequency in Japan and that reported in several other countries was significant. We did not find any association between ACE gene polymorphism and essential hypertension in Japan. However, there were significant differences in derived allele frequencies between our findings in a Japanese population and those reported from Europe and Australia.

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ID Code: 62946
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/0006-291X(92)91150-O
ISSN: 0006-291X
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1992 Elsevier Inc.
Deposited On: 26 Sep 2013 04:25
Last Modified: 26 Sep 2013 04:25

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