Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives

Zee, Robert Y., Griffiths, Lyn R., & Morris, Brian J. (1992) Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives. Biochemical and Biophysical Research Communications, 189(2), pp. 965-971.

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RFLPs at the low density lipoprotein receptor locus (LDLR) display marked linkage disequilibrium between each other. Cross-sectional analysis of a bi-alleleic ApaLI RFLP of LDLR showed that the 9.4- and 6.6-kb alleles were present in similar frequency between a group of 84 Caucasian essential hypertensive (HT) and a group of 96 normotensive subjects whose parents each had a similar blood pressure status at age > or = 50. After subdividing HTs into lean and obese, however, the frequency of the 6.6-kb allele in the 27 HTs with BMI > or = 26 kg/m2 was 0.63, compared with 0.39 for HTs with BMI < 26 (chi 2 = 8.8; P = 0.004). The difference in genotype frequencies was even more striking (chi 2 = 23; P = 0.00008), with a virtual absence of 9.4-kb homozygotes in the obese HT group (1 vs 22). Genetic variation at LDLR (19p13.2) is thus associated with obesity in HT.

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ID Code: 62947
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/0006-291X(92)92298-C
ISSN: 0006-291X
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1992 Elsevier
Deposited On: 26 Sep 2013 04:30
Last Modified: 26 Sep 2013 04:30

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