Phenotypic changes in artemisinin-resistant plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition

Teuscher, Franka, Chen, Nanhua, Kyle, Dennis E., Gatton, Michelle L., & Cheng, Qin (2012) Phenotypic changes in artemisinin-resistant plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition. Antimicrobial Agents and Chemotherapy, 56(1), pp. 428-431.

View at publisher

Abstract

The appearance of Plasmodium falciparum parasites with decreased in vivo sensitivity but no measurable in vitro resistance to artemisinin has raised the urgent need to characterize the artemisinin resistance phenotype. Changes in the temporary growth arrest (dormancy) profile of parasites may be one aspect of this phenotype. In this study, we investigated the link between dormancy and resistance, using artelinic acid (AL)-resistant parasites. Our results demonstrate that the AL resistance phenotype has

(i) decreased sensitivity of mature-stage parasites,

(ii) decreased sensitivity of the ring stage to the induction of dormancy, and

(iii) a faster recovery from dormancy.

Impact and interest:

20 citations in Scopus
Search Google Scholar™
21 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

33 since deposited on 30 Jun 2014
2 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 62965
Item Type: Journal Article
Refereed: Yes
Keywords: Plasmodium falciparum, Artemisinin, resistance, malaria
DOI: 10.1128/AAC.05456-11
ISSN: 1098-6596
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL MICROBIOLOGY (110800) > Medical Parasitology (110803)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Public Health & Social Work
Funding:
  • NIH/R01-AI058973
Copyright Owner: Copyright 2012 American Society for Microbiology
Deposited On: 30 Jun 2014 22:37
Last Modified: 01 Jul 2014 22:39

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page