Examination of the role of nitric oxide synthase and renal kallikrein as candidate genes for essential hypertension

Friend, L. R., Morris, Brian J., Gaffney, Philip T., & Griffiths, Lyn R. (1996) Examination of the role of nitric oxide synthase and renal kallikrein as candidate genes for essential hypertension. Clinical and Experimental Pharmacology and Physiology, 23(6-Jul), pp. 564-566.

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Nitric oxide synthase and renal kallikrein are both involved in blood pressure regulation. Genes for these enzymes may, therefore, be considered candidates for hypertension pathogenesis. 2. In the present study, genotypes for nitric oxide synthase and renal kallikrein microsatellite markers were determined in a cross-sectional association analysis of hypertensive patients and normotensive control subjects. 3. Results from this study did not indicate an association of either of the candidate gene polymorphisms with essential hypertension. Hence, findings for this study do not support a role for these genes in human hypertension.

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ID Code: 62998
Item Type: Journal Article
Refereed: Yes
Keywords: association studies, essential hypertension, human genetics, microsatellite, kallikrein, microsatellite dna, nitric oxide synthase, adult, conference paper, controlled study, essential hypertension, female, genetic linkage, genetic polymorphism, genotype, human, inheritance, major clinical study, male, Alleles, Female, Genotype, Humans, Hypertension, Kallikreins, Kidney, Male, Microsatellite Repeats, Middle Aged, Nitric Oxide Synthase, Polymorphism, Genetic
ISSN: 0305-1870
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1996 Wiley-Blackwell Publishing Asia
Deposited On: 27 Sep 2013 04:46
Last Modified: 27 Sep 2013 04:46

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