Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis

Zhou, Yinghong (2013) Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis. PhD by Publication, Queensland University of Technology.

Abstract

The body of work presented in this dissertation has demonstrated that the interactions between donor cells and host cells are critical for bone repair and regeneration. The donor cells secrete VEGF which activates the downstream PI3K/Akt signaling pathway, ultimately leading to host cell recruitment and robust bone regeneration. The findings from this dissertation may provide a scientific rationale for the development of novel therapeutic strategies in the treatment and management of bone defects.

Impact and interest:

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Full-text downloads:

228 since deposited on 30 Sep 2013
30 in the past twelve months

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ID Code: 63002
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Xiao, Yin & Crawford, Ross W.
Keywords: bone regeneration, bone tissue engineering, cell-based therapy, cell interaction, cell recruitment, mesenchymal stromal cells (MSCs), osteogenesis, differentiation
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 30 Sep 2013 00:43
Last Modified: 31 Aug 2015 23:02

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