Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis
Zhou, Yinghong (2013) Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis. PhD by Publication, Queensland University of Technology.
The body of work presented in this dissertation has demonstrated that the interactions between donor cells and host cells are critical for bone repair and regeneration. The donor cells secrete VEGF which activates the downstream PI3K/Akt signaling pathway, ultimately leading to host cell recruitment and robust bone regeneration. The findings from this dissertation may provide a scientific rationale for the development of novel therapeutic strategies in the treatment and management of bone defects.
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|Item Type:||QUT Thesis (PhD by Publication)|
|Supervisor:||Xiao, Yin & Crawford, Ross W.|
|Keywords:||bone regeneration, bone tissue engineering, cell-based therapy, cell interaction, cell recruitment, mesenchymal stromal cells (MSCs), osteogenesis, differentiation|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Institution:||Queensland University of Technology|
|Deposited On:||30 Sep 2013 00:43|
|Last Modified:||31 Aug 2015 23:02|
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