Cross-sectional study of a microsatellite marker in the low densitity lipoprotein receptor gene in obese normotensives

Griffiths, Lyn R., Nyholt, Dale R., Curtain, Robert P., Gaffney, Philip T., & Morris, Brian J. (1995) Cross-sectional study of a microsatellite marker in the low densitity lipoprotein receptor gene in obese normotensives. Clinical and Experimental Pharmacology and Physiology, 22(6-Jul), pp. 496-498.

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Abstract

  1. The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity. In this study, genotypes for a low density lipoprotein receptor gene (LDLR) dinucleotide polymorphism were determined in both lean and obese normotensive populations.

  2. In previous cross-sectional association studies an ApaLI and a HincII polymorphism for LDLR were shown to be associated with obesity in essential hypertensives. However, these polymorphisms did not show an association with obesity in normotensives.

  3. In contrast, this study reports that preliminary results for an LDLR microsatellite marker, located more towards the 3' end of the gene, show a significant association with obesity in the normotensive population studied. These results indicate that LDLR could play an important role in the development of obesity, which might be independent of hypertension.

Impact and interest:

16 citations in Scopus
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19 citations in Web of Science®

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ID Code: 63010
Item Type: Journal Article
Refereed: Yes
Keywords: Association studies, Molecular genetics, Obesity, PCR, Polymorphism, low density lipoprotein receptor, conference paper, controlled study, human, major clinical study, molecular genetics, obesity, polymerase chain reaction, Chi-Square Distribution, Cholesterol, Comparative Study, Cross-Sectional Studies, DNA, Satellite, Electrophoresis, Polyacrylamide Gel, Genetic Markers, Genotype, Human, Hypertension, Obesity, Polymerase Chain Reaction, Polymorphism (Genetics), Receptors, LDL, Repetitive Sequences, Nucleic Acid, Support, Non-U.S. Gov't
ISSN: 0305-1870
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1995 Wiley-Blackwell Publishing Asia
Deposited On: 27 Sep 2013 06:50
Last Modified: 20 May 2015 00:31

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