Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism

Griffiths, Lyn R., Nyholt, Dale R., Curtain, Robert P., Goadsby, Peter J., & Brimage, Peter J. (1997) Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism. Neurology, 49(2), 0614-617.


Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls the synthesis of nitric oxide, could possibly be a cause, or candidate gene, in migraine etiology. In this study, we detected a polymorphism for endothelial nitric oxide synthase by polymerase chain reaction and tested this for association and linkage to migraine. Results from the study did not show an association of the nitric oxide synthase microsatellite when tested in 91 affected and 85 unaffected individuals. Using the FASTLINK program for parametric linkage analysis, the polymorphism did not show significant linkage to migraine when tested in four migraine pedigrees composed of 116 individuals, 52 affected. Total LOD scores excluded linkage up to 8.5 cM between the nitric oxide synthase polymorphism and migraine. Results using the nonparametric affected pedigree member form of analysis also did not support a role for this gene in migraine etiology.

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35 citations in Web of Science®
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ID Code: 63011
Item Type: Journal Article
Refereed: Yes
Keywords: nitric oxide, nitric oxide synthase, article, clinical protocol, clinical trial, controlled clinical trial, controlled study, endothelium, familial disease, female, genetic association, genetic linkage, genetic polymorphism, human, human cell, major clinical study, male, migraine, nociception, pedigree, polymerase chain reaction, priority journal, vasodilatation, Alleles, Endothelium, Vascular, Genes, Genotype, Humans, Linkage (Genetics), Lod Score, Migraine Disorders, Nitric Oxide Synthase, Pedigree, Polymorphism, Genetic
ISSN: 0028-3878
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1997 Lippincott Williams & Wilkins
Deposited On: 27 Sep 2013 06:56
Last Modified: 20 May 2015 00:28

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