Regional chromosomal assignment of human renin gene to 1q12→qter and use in linkage studies in Charcot-Marie-Tooth disease

Griffiths, Lyn R., Nicholson, G. A., Ross, D. A., Zwi, M. B., McLeod, J. G., Mohandas, T., & Morris, B. J. (1987) Regional chromosomal assignment of human renin gene to 1q12→qter and use in linkage studies in Charcot-Marie-Tooth disease. Cytogenetics and Cell Genetics, 45(3-Apr), pp. 231-233.

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The gene for renin, previously mapped to human chromosome 1, was further localized to 1q12 → qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (λ HR5) could detect a HindIII restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.

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8 citations in Web of Science®
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ID Code: 63013
Item Type: Journal Article
Refereed: No
Keywords: radioisotope, renin, cell culture, chromosome 1q, cytology, dna probe, gene assignment, gene location, gene mapping, genetic engineering, genetic linkage, hereditary motor sensory neuropathy, heredity, human, human cell, hypertension, normal value, Animal, Charcot-Marie-Tooth Disease, Chromosome Mapping, Chromosomes, Human, Pair 1, Female, Genes, Structural, Human, Hybrid Cells, Linkage (Genetics), Male, Mice, Muscular Atrophy, Spinal, Pedigree, Renin, Support, Non-U.S. Gov't
ISSN: 0301-0171
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1987 S. Karger AG
Deposited On: 27 Sep 2013 07:24
Last Modified: 27 Sep 2013 07:27

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