A locus on the long arm of chromosome 1 as a possible cause of essential hypertension

Griffiths, Lyn R., Zee, Robert Y., Ying, L.-H., & Morris, B. J. (1991) A locus on the long arm of chromosome 1 as a possible cause of essential hypertension. Clinical and Experimental Pharmacology and Physiology, 18(5), pp. 363-366.

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None of the genes responsible for essential hypertension has been identified. Recent work in genetically hypertensive rats has shown linkage of blood pressure with alleles of the renin gene. Since the renin gene is a member of a conserved synteny group that in humans spans chromosome 1q21.3-32.3 and includes the gene for antithrombin III (AT3), we used linkage studies to examine the relationship between alleles of AT3 and hypertension in a family having 10 affected members. From the lod score obtained at a recombination fraction of zero the odds for linkage of AT3 and hypertension in this family were calculated as 6:1 in favour of linkage. This result provides grounds for further examination of the possible role of the 1q23 locus in the aetiology of essential hypertension.

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ID Code: 63017
Item Type: Journal Article
Refereed: Yes
Additional Information: 1676620
Keywords: antithrombin III, chromosome 1, human genetics, linkage analyses, LIPED, RFLP, antithrombin iii, chromosome disorder, conference paper, essential hypertension, genetics, human, human cell, major clinical study, priority journal, Antithrombin III, Blotting, Southern, Chromosomes, Human, Pair 1, Family Health, Human, Hypertension, Linkage (Genetics), Polymorphism, Restriction Fragment Length, Support, Non-U.S. Gov't
ISSN: 0305-1870
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1991 Wiley-Blackwell Publishing Asia
Deposited On: 27 Sep 2013 07:50
Last Modified: 27 Sep 2013 07:50

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