Synthesis of Soluble Phosphate Polymers by RAFT and Their In Vitro Mineralization

Suzuki, Shuko, Whittaker, Michael R., Grondahl, Lisbeth, Monterio, Michael J., & Wentrup-Byrne, Edeline (2006) Synthesis of Soluble Phosphate Polymers by RAFT and Their In Vitro Mineralization. Biomacromolecules, 7(11), pp. 3178-3187.

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Soluble linear (non-crossed linked) poly(monoacryloxyethyl phosphate) (PMAEP) and poly(2-(methacryloyloxy)ethyl phosphate) (PMOEP) have been successfully synthesised through reversible addition fragmentation chain transfer (RAFT) mediated polymerization. Our findings indicate diene impurities are the cause of crosslinking initially and this suggests that crosslinking can be prevented to a low chain length. Block copolymers consisting of PMAEP or PMOEP and poly(2-(acetoacetoxy) ethyl methacrylate) PAAEMA were successfully prepared and were immobilised on aminated slides. Simulated body fluid studies revealed that calcium phosphate (CaP) minerals formed on both the soluble polymers and their gels were very similar. Both the PMAEP polymers and the PMOEP gel showed a CaP layer most probably brushite or monetite based on the Ca/P ratios. A secondary CaP mineral growth with a typical hydroxyapatite (HAP) globular morphology was found on the PMOEP gel. The soluble-PMOEP film formed carbonated HAP according to Fourier transform infrared (FTIR) spectroscopy. Block copolymers attached to aminated slides showed only patchy mineralization, possibly due to the ionic interaction of negatively charged phosphate groups and protonated amines.

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48 citations in Web of Science®
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ID Code: 6304
Item Type: Journal Article
Refereed: Yes
Additional Information: This article is freely available from the American Chemical Society website 12 months after the publication date. See links to publisher website in this record.
Keywords: phosphate polymers, RAFT, mineralization
DOI: 10.1021/bm060583q
ISSN: 1525-7797
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2006 American Chemical Society
Copyright Statement: The contents of this journal can be freely accessed online via the ACS web page 12 months after publication. See hypertext link.
Deposited On: 26 Feb 2007 00:00
Last Modified: 29 Feb 2012 13:26

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