High resolution melt analysis : a novel method for studying the genetic relatedness of Pseudomonas aeruginosa isolates from clinical and environmental sources

Watts, Annabelle Monica (2013) High resolution melt analysis : a novel method for studying the genetic relatedness of Pseudomonas aeruginosa isolates from clinical and environmental sources. Masters by Research thesis, Queensland University of Technology.

Abstract

A novel method was developed for studying the genetic relatedness of Pseudomonas aeruginosa isolates from clinical and environmental sources. This bacterium is ubiquitous in the natural environment and is an important pathogen known to infect Cystic Fibrosis (CF) patients. The transmission route of strains has not yet been defined; current theories include acquisition from an environmental source or through patient-to-patient spread. A highly discriminatory, bioinformatics based, DNA typing method was developed to investigate the relatedness of clinical and environmental isolates. This study found a similarity between the environmental and several CF clonal strains and also highlighted occurrence of environmental P. aeruginosa strains in CF infections.

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ID Code: 63094
Item Type: QUT Thesis (Masters by Research)
Supervisor: Huygens, Flavia & Hargreaves, Megan
Keywords: High Resolution Melt Analysis, Pseudomonas aeruginosa, Cystic Fibrosis, Genotyping, SNP
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 08 Oct 2013 05:06
Last Modified: 09 Sep 2015 21:46

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