An investigation of the 5-HT2C receptor gene as a migraine candidate gene

Johnson , Matthew P., Lea, Rod A., Curtain, Robert P., MacMillan, John C., & Griffiths, Lyn R. (2003) An investigation of the 5-HT2C receptor gene as a migraine candidate gene. American Journal of Medical Genetics - Neuropsychiatric Genetics, 117B(1), pp. 86-89.

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Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT2C) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT2C gene. In addition, exonic coding regions of the 5-HT2C gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT 2C gene in migraine predisposition. © 2003 Wiley-Liss, Inc.

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ID Code: 63129
Item Type: Journal Article
Refereed: Yes
Additional Information: 12555241
Keywords: 5-HT2C, Association, Linkage, Migraine, serotonin 2C receptor, serotonin 2C receptor, serotonin receptor, article, gene function, genetic association, genetic linkage, genetic predisposition, human, migraine, pedigree, priority journal, X chromosome linked disorder, case control study, female, gene frequency, genetics, genotype, male, sex difference, single nucleotide polymorphism, X chromosome, Case-Control Studies, Chromosomes, Human, X, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Migraine Disorders, Polymorphism, Single Nucleotide, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, Sex Factors
DOI: 10.1002/ajmg.b.10007
ISSN: 1552-4841
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 John Wiley & Sons, Inc.
Deposited On: 04 Oct 2013 01:14
Last Modified: 02 Jul 2014 22:49

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