Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree

Rodriquez-Acevedo, A. J., Maher, B. H., Benton, M., Lea, Rod A., & Griffiths, Lyn R. (2013) Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree. Cephalalgia, 33(14), pp. 1139-1147.

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Abstract

BACKGROUND: Oestrogen receptor 1 ( ESR1) is located in region 6q25.1 and encodes a ligand-activated transcription factor composed of several domains important for hormone binding and transcription activation. Progesterone receptor ( PGR) is located in 11q22-23 and mediates the role of progesterone interacting with different transcriptional co-regulators. ESR1 and PGR have previously been implicated in migraine susceptibility. Here, we report the results of an association study of these genes in a migraine pedigree from the genetic isolate of Norfolk Island, a population descended from a small number of Isle of Man "Bounty Mutineer" and Tahitian founders.

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ID Code: 63185
Item Type: Journal Article
Refereed: Yes
DOI: 10.1177/0333102413486321
ISSN: 1468-2982
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Sage Publications Ltd.
Deposited On: 08 Oct 2013 01:57
Last Modified: 02 Jul 2014 22:40

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