High performance liquid chromatography determined alkamide levels in Australian-grown Echinacea spp.

Rogers, Kelly L., Grice, I. Darren, Mitchell, C. J., & Griffiths, Lyn R. (1998) High performance liquid chromatography determined alkamide levels in Australian-grown Echinacea spp. Australian Journal of Experimental Agriculture, 38(4), pp. 403-408.

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Extracts of Echinacea spp. are widely used as therapeutic immunostimulants with such activity being attributed in part to the alkamide fractions of these plants. Using high performance liquid chromatography, the levels of 8 alkamides, including 2 tetraene alkamides (dodeca-2E, 4E, 8Z, 10E/Z-tetraenoic acid isobutylamide), were quantitatively determined in 2 Australian-grown Echinacea spp. Overall, the levels of alkamides in Australian-grown E. angustifolia were found to be comparable with levels obtained in this study and other studies for USA and European Echinacea spp. However, results obtained for one sample of E. angustifolia suggested that it may have been mislabelled and that it was most likely a sample of E. pallida. Levels of tetraene alkamides in Australian-grown E. purpurea were also similar to, if not higher, than levels which have been reported for the same species grown in Germany and the USA. Preliminary studies on the stability of alkamide compounds in E. angustifolia indicated that they are susceptible to degradation, with a 13% loss of alkamide level over 2 months. Overall, results indicate that there is considerable potential to develop Echinacea as a viable crop in Australia.

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ID Code: 63187
Item Type: Journal Article
Refereed: No
Keywords: 10E/Z-tetraenoic acid, 4E, 8Z, Dodeca-2E, Isobutylamide, Isobutylamides, Tetraene alkamides, Echinacea angustifolia, Echinacea pallida, Echinacea purpurea
ISSN: 0816-1089
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1998 Commonwealth Scientific and Industrial Research Organization
Deposited On: 08 Oct 2013 02:10
Last Modified: 08 Oct 2013 02:10

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