Association of a low density lipoprotein receptor microsatellite variant with obesity

Rutherford, S., Nyholt, D.R., Curtain, R.P., Quinlan, S.R., Gaffney, P.T., Morris, B.J., & Griffiths, L.R. (1997) Association of a low density lipoprotein receptor microsatellite variant with obesity. International Journal of Obesity, 21(11), pp. 1032-1037.

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To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity.


A cross-sectional case-control study.


One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2.


BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp).


There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2 = 12.3, P = 0.002), but not in males (χ2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese.


These results suggest that in females, LDLR may play a role in the development of obesity.

Impact and interest:

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18 citations in Web of Science®

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ID Code: 63190
Item Type: Journal Article
Refereed: Yes
Additional Information: 9368827
Keywords: Association study, BMI, Microsatellite polymorphism, Molecular genetics, Obesity, PCR, lipid, low density lipoprotein receptor, microsatellite dna, allele, article, blood pressure measurement, body mass, controlled study, dna polymorphism, female, human, human experiment, lipid blood level, male, obesity, polymerase chain reaction, priority journal, Alleles, Analysis of Variance, Body Mass Index, Case-Control Studies, Cross-Sectional Studies, Female, Genotype, Humans, Hypertension, Lipids, Male, Microsatellite Repeats, Obesity, Polymorphism, Genetic, Receptors, LDL
ISSN: 0307-0565
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1997 Nature Publishing Group
Deposited On: 08 Oct 2013 02:25
Last Modified: 20 May 2015 00:30

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