Prevalence of chronic ocular diseases in a genetic isolate : the Norfolk Island Eye Study (NIES)
Sherwin, J. C., Kearns, L. S., Hewitt, A. W., Marin, Y., Kelly, J., Griffiths, Lyn R., & Mackey, D. A. (2011) Prevalence of chronic ocular diseases in a genetic isolate : the Norfolk Island Eye Study (NIES). Ophthalmic Epidemiology, 18(2), pp. 61-71.
Purpose: Over 40% of the permanent population of Norfolk Island possesses a unique genetic admixture dating to Pitcairn Island in the late 18 th century, with descendents having varying degrees of combined Polynesian and European ancestry. We conducted a population-based study to determine the prevalence and causes of blindness and low vision on Norfolk Island. Methods: All permanent residents of Norfolk Island aged ≥ 15 years were invited to participate. Participants completed a structured questionnaire/interview and underwent a comprehensive ophthalmic examination including slit-lamp biomicroscopy. Results: We recruited 781 people aged ≥ 15, equal to 62% of the permanent population, 44% of whom could trace their ancestry to Pitcairn Island. No one was bilaterally blind. Prevalence of unilateral blindness (visual acuity [VA] < 6/60) in those aged ≥ 40 was 1.5%. Blindness was more common in females (P=0.049) and less common in people with Pitcairn Island ancestry (P<0.001). The most common causes of unilateral blindness were age-related macular degeneration (AMD), amblyopia, and glaucoma. Five people had low vision (Best-Corrected VA < 6/18 in better eye), with 4 (80%) due to AMD. People with Pitcairn Island ancestry had a lower prevalence of AMD (P<0.001) but a similar prevalence of glaucoma to those without Pitcairn Island ancestry. Conclusions: The prevalence of blindness and visual impairment in this isolated Australian territory is low, especially amongst those with Pitcairn Island ancestry. AMD was the most common cause of unilateral blindness and low vision. The distribution of chronic ocular diseases on Norfolk Island is similar to mainland Australian estimates.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||Blindness, Epidemiology, Genetics, Glaucoma, Macular degeneration, Norfolk Island, Pitcairn Island, Population isolates, adolescent, adult, aged, amblyopia, article, chronic disease, eye examination, female, glaucoma, human, interview, major clinical study, male, Pitcairn, population research, prevalence, priority journal, retina macula age related degeneration, slit lamp, structured questionnaire, unilateral blindness, visual acuity, Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Blindness, Eye Diseases, Hereditary, Female, Functional Laterality, Genetics, Population, Humans, Male, Melanesia, Middle Aged, Oceanic Ancestry Group, Prevalence, Questionnaires, Sex Distribution, Vision, Low, Visual Acuity, Visually Impaired Persons, Young Adult|
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Copyright Owner:||Copyright 2011 Informa Healthcare|
|Deposited On:||08 Oct 2013 02:31|
|Last Modified:||11 Nov 2013 21:47|
Repository Staff Only: item control page