A genetic variant located in miR-423 is associated with reduced breast cancer risk

Smith, R. A., Jedlinski, D. J., Gabrovska, Plamena N., Weinstein, S. R., Haupt, Larisa M., & Griffiths, Lyn R. (2012) A genetic variant located in miR-423 is associated with reduced breast cancer risk. Cancer Genomics and Proteomics, 9(3), pp. 115-118.

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Background/Aim: Since microRNAs (miRNAs) act as translational regulators of multiple genes, single nucleotide polymorphisms (SNP) in them can have potentially wide-ranging effects. Using an association approach, this research examined the effects of the rs6505162 SNP, an A>C polymorphism located in the premiRNA region of miR-423, on breast cancer development. Materials and Methods: Caucasian Australian women with breast cancer and controls matched for age and ethnicity were genotyped for rs6505162 and their genotypic and allelic frequencies analysed for significant differences. Results: Analysis indicated that there were significant differences between the case and control populations (χ 2=6.70, p=0.035), with the CC genotype conferring reduced risk of breast cancer development (odds ratio=0.50 95% confidence interval=0.27-0.92, p=0.03). Conclusion: Further functional research is required to determine the mechanism of action of this SNP on miRNA function.

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ID Code: 63192
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website
Keywords: Breast cancer, Cancer risk, MicroRNA, miR-423, SNP, microRNA, mirna 423, unclassified drug, adult, article, breast cancer, cancer risk, carcinogenesis, controlled study, ethnicity, female, gene frequency, genetic variability, genotype, human, major clinical study, male, single nucleotide polymorphism, Breast Neoplasms, Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Humans, MicroRNAs, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors
ISSN: 1109-6535
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 International Institute of Anticancer Research
Deposited On: 08 Oct 2013 02:55
Last Modified: 22 Jan 2015 06:23

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