Genetic variation in cytokine-related genes and migraine susceptibility

Stuart, Shani, Maher, Bridget H., Sutherland, Heidi, Benton , Miles, Rodriguez, Astrid, Lea, Rod A., Haupt, Larisa M., & Griffiths, Lyn R. (2013) Genetic variation in cytokine-related genes and migraine susceptibility. Twin Research and Human Genetics, 16(6), pp. 1079-1086.

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Abstract

Migraine is classified by the World Health Organization (WHO) as being one of the top 20 most debilitating diseases. According to the neurovascular hypothesis, neuroinflammation may promote the activation and sensitisation of meningeal nociceptors, inducing the persistent throbbing headache characterized in migraine. The tumor necrosis factor (TNF) gene cluster, made up of TNFα, lymphotoxin α (LTA), and lymphotoxin β (LTB), has been implicated to influence the intensity and duration of local inflammation. It is thought that sterile inflammation mediated by LTA, LTB, and TNFα contributes to threshold brain excitability, propagation of neuronal hyperexcitability and thus initiation and maintenance of a migraine attack. Previous studies have investigated variants within the TNF gene cluster region in relation to migraine susceptibility, with largely conflicting results. The aim of this study was to expand on previous research and utilize a large case-control cohort and range of variants within the TNF gene cluster to investigate the role of the TNF gene cluster in migraine. Nine single nucleotide polymorphisms (SNPs) were selected for investigation as follows: rs1800683, rs2229094, rs2009658, rs2071590, rs2239704, rs909253, rs1800630, rs1800629, and rs3093664. No significant association with migraine susceptibility was found for any of the SNPs tested, with further testing according to migraine subtype and gender also showing no association for disease risk. Haplotype analysis showed that none of the tested haplotypes were significantly associated with migraine.

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ID Code: 63194
Item Type: Journal Article
Refereed: Yes
Additional Information: Stuart, Shani
Maher, Bridget H
Sutherland, Heidi
Benton, Miles
Rodriguez, Astrid
Lea, Rod A
Haupt, Larisa M
Griffiths, Lyn R
eng
Research Support, Non-U.S. Gov't
England
2013/09/24 06:00
Twin Res Hum Genet. 2013 Dec;16(6):1079-86. doi: 10.1017/thg.2013.63. Epub 2013 Sep 20.
Keywords: Migraine, SNPs, cytokine
DOI: 10.1017/thg.2013.63
ISSN: 1839-2628
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Cambridge University Press
Deposited On: 08 Oct 2013 03:16
Last Modified: 02 Jul 2014 22:41

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