Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension

Ying, L.-H., Zee, R. Y., Griffiths, Lyn R., & Morris, B. J. (1991) Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension. Biochemical and Biophysical Research Communications, 181(1), pp. 486-492.

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Abstract

Insulin has cardiovascular actions and patients with essential hypertension display insulin resistance. A cross-sectional study of the R1 RFLP of the insulin receptor gene (INSR) was carried out in 67 hypertensive (HT) and 75 normotensive (NT) subjects whose parents had a similar blood pressure status at age ≥50. The frequency of the minor (+) allele was 0.31 in HTs and 0.44 in NTs, and the difference between observed alleles in all subjects in each group was significant (χ2 = 4.8, P<0.05). Allele frequencies of a BglI RFLP of the insulin gene, however, did not differ between the HT and NT groups. The data thus provide evidence in favour of an association of HT with a polymorphism at the INSR locus (19p 13.3-13.2), so implicating this locus, and possibly a genetic variant of the insulin receptor itself, in HT.

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45 citations in Web of Science®
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ID Code: 63195
Item Type: Journal Article
Refereed: Yes
Additional Information: 1683535
Keywords: insulin receptor, article, controlled study, essential hypertension, human, insulin resistance, major clinical study, priority journal, restriction fragment length polymorphism, Adult, Aged, Alleles, Blood Pressure, Chromosome Mapping, Chromosomes, Human, Pair 19, Deoxyribonucleases, Type II Site-Specific, DNA, DNA Probes, Gene Frequency, Genotype, Human, Hypertension, Insulin, Leukocytes, Polymorphism, Restriction Fragment Length, Receptor, Insulin, Reference Values, Support, Non-U.S. Gov't
ISSN: 0006-291X
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1991 Elsevier Inc.
Deposited On: 08 Oct 2013 03:21
Last Modified: 08 Oct 2013 03:21

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