Non-linkage of insulin receptor locus with essential hypertension in an affected pedigree
Ying, L.-H., Zee, R. Y., Griffiths, Lyn R., & Morris, B. J. (1993) Non-linkage of insulin receptor locus with essential hypertension in an affected pedigree. Hypertension Research - Clinical and Experimental, 16(1), pp. 25-28.
A recent cross-sectional study has demonstrated a significant association of the R1 RsaI restriction fragment length polymorphism of the insulin receptor gene (INSR) with human essential hypertension. In the present study, an alternative approach, involving linkage analysis, was carried out using 8 hypertensive families with 5 or more affected members. Five of the families were found to be informative and in one of these pedigrees a conclusion of non-linkage of INSR and hypertension could be made on the basis of an obligate recombinant in one generation which yielded a Lod score of - ∞ at a recombination fraction (θ) of zero. In another family, the largest studied, a positive Lod score was obtained at θ = 0, but this was below the level required for a conclusion of linkage. Lod score at θ = 0 for a marker at the insulin locus in this family was negative. The present study has thus demonstrated one pedigree in which hypertension is not linked to the insulin receptor locus.
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|Item Type:||Journal Article|
|Keywords:||alleles, blood pressure, LIPED, molecular genetics, RsaI RFLP, insulin receptor, article, controlled study, essential hypertension, gene locus, genetic linkage, human, major clinical study, molecular genetics, pedigree analysis, restriction fragment length polymorphism|
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Copyright Owner:||Copyright 1993 Nature Publishing Group|
|Deposited On:||08 Oct 2013 04:05|
|Last Modified:||08 Oct 2013 04:05|
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